Maia Al-Masri

November 2015

Epithelial cells are major sites of malignant transformation (in over 80% of cancers), and evidence indicates that apical-basal cell polarity provides a tumour-suppressive function. In fact, accumulating evidence suggests that loss of polarity is a permissive step in cancer progression. Major metabolic adaptations occur in cancer cells that help fuel growth and aid in the evasion of apoptosis, and polarity proteins may well be positioned to influence metabolic reprogramming through interactions between prominent regulators and pathways of both processes.