Montreal International Symposium on Angiogenesis and Metastasis

"Treating Disseminated Cancer by Targeting the Epigenome"
June 15 -17, 2016
Montreal (Quebec) Canada


It is with a great pleasure that we invite you to the Montreal International Symposium on Angiogenesis and Metastasis – MISAM, which will take place in historic and beautiful Montreal on June 15-17, 2016. This bi-annual event aims to bring together scientists working in areas related to disseminated disease, angiogenesis and metastasis in order to tackle together this great challenge common to all cancers, but yet so diverse.

Oncology has progressed over the past decades such that many primary tumors are treatable using multiple modalities. We have been far less successful, however, in fighting the systemic processes in cancer, such as recurrent and metastatic growth, which is often refractory to treatment and remains the major cause for morbidity and mortality across the spectrum of human malignancies. As such, deciphering molecular changes that lead to formation of distant metastases and govern their behavior represents the critical research frontier in understanding cancer today.

As much as stunning improvements in technologies of genomics revealed the unsuspected mutational landscape of many human cancers, it became clear that alteration in DNA sequences alone cannot account for activation of all of the proliferative, invasive and angiogenic programs that drive tumor progression and metastatic dissemination. Indeed, it is increasingly obvious that the aberrant reprogramming of epigenetic regulation of molecular information represents a key step fueling multiple oncogenic changes in the cellular phenotype.

Epigenetics is viewed as a diverse ensemble of mechanisms and molecular factors that are capable of regulating gene expression independently of DNA sequence, and in a stable manner over cycles of cell division. Common epigenetic events include changes in the accessibility of the genetic code through modified DNA methylation (and other modifications), alterations in non-coding RNA expression patterns and function, changes in the chromatin architecture, including post-translational modification of histones and their associated proteins, and incorporation of histone variants into nucleosomes. Such events regulate the three-dimensional structure of the genome and compartmentalization of the phenotypic programs at the level of chromatin, all of which could become targets and drivers of malignant transformation.

The goal of the 2016 MISAM is to reflect the tremendous progress that has occurred during recent years in understanding and therapeutic modulation of the advanced cancer epigenome. Participants will discuss new insights into key epigenetic processes that are commonly deregulated during cancer formation and metastatic progression. Novel therapeutic avenues targeting the epigenome will be explored, to better combat systemic propagation of cancers.

The program at the 2016 MISAM meeting includes seminars from Stephen Baylin, Gary Felsenfeld, Michael Taylor, Raghu Kalluri, Peter Lewis, Yibin Kang, Emily Bernstein, Joseph Costello, Cheryl Arrowsmith, Frank Slack, Lin He, Tom Muir, Mathieu Lupien and Daniel De Carvalho amongst many other prominent researchers in the field in epigenetics. As different human malignancies progress along different biological trajectories, so too will the program explore different disease contexts and dimensions of the advanced cancer epigenome. Together with participants from across the globe, we hope to create a discussion that will profoundly impact your research perspective and change the way we all understand cancer as a disease!

We offer you a unique program filled with the latest advances, as well as emerging concepts and ideas in key areas of epigenetic research, and their possible impact on cancer treatment.  We hope to stimulate discussions that will continue outside of the lecture halls and extend beyond the two-day symposium.  Our city with its picturesque streets, world-renowned restaurants and long-standing tradition of thought, learning, science and humanism will provide the ideal surrounding for this exciting exchange of ideas.

We invite you to MISAM 2016 and to Montreal.
The Organizing Committee


Important Dates

Symposium dates: June 15 - 17, 2016
Registration and abstract submission opens: March 1, 2016
Abstract submission closes: April 30, 2016
Registration closes: May 31, 2016

Distinguished Speakers

Raghu Kalluri, MD, PhD
Principal Investigator
University of Texas
MD Anderson Cancer Center
Houston, Texas, USA

Title: "The Biology and Function of Exosomes in Pancreatic Cancer"
Biography and research Interest


Stephen B. Baylin, MD
Virginia and D.K. Ludwig Professor for Cancer Research
Professor of Oncology and Medicine
The Johns Hopkins University School of Medicine,
Baltimore, MD, USA

Title: "The evolution of epigenetic abnormalities in cancer –
their role in altering the balance between cell self-renewal and differentiation"

Biography and research interest

Early registration includes abstract submission:
March 1, 2016 until April 30, 2016

Students and Postdoctoral Fellows: $125.00
Scientists and Clinicians: $150.00

Late registration (abstract submission is closed):
May 1 until May 31, 2016

Students and Postdoctoral Fellows: $175.00
Scientists and Clinicians: $200.00


Important notes:

  • Attendees must register in order to be able to submit an abstract via an online link.
  • The online registration closes on midnight May 31, 2016.
  • There will be no registration on site.
  • Students and Postdoctoral Fellows must bring a letter from their supervisor confirming their trainee status.
  • Selection of abstracts for oral presentation: May 15, 2016.
  • Please see Awards for more information.

Included in the registration fees are:

  • Attendance of the Distinguished Lectures on June 15, 2016.
  • Admission to the symposium on June 16 & 17, 2016.
  • Conference materials.
  • Participation in the poster presentation reception.
  • Light breakfasts, buffet lunches, and refreshment breaks.

Cancellation policy:

  • Cancellations must be received at least 30 days prior to the meeting date to receive a refund less $25 handling fee.
  • There will be no refund for cancellations received less than 30 days prior to the meeting.

Photo release statement
MISAM may use photos of MISAM 2016 attendees in their promotional materials. By virtue of your attendance, it is assumed that you agree to the usage of your likeness in such materials. If you do object to having your photo taken, please advise the photographer.

Please note that all abstracts must be submitted online at the time of the registration and by the specified deadline of April 30th, 2016.

The 3 best abstracts will be selected for oral presentation by May 15, 2016. Authors of these abstracts will be notified via email when selected.

Abstract submission instructions:

  • Only trainees can submit an abstract.
  • One abstract per trainee can be submitted.
  • The abstract must be submitted in English.
  • The title of an abstract must be followed by the list of authors.
  • Presenting author’s name must be underlined in the list of authors.
  • The abstract text must be single-spaced and no more than 2500 characters long (including spaces).
  • The page margins must be: 1 inch (Top, Bottom, Left and Right).
  • The font size should be 12 points.
  • The font type should be Times New Roman.
  • The grant acknowledgments are to be placed at the end of the abstract.

Oral Presentation Guidelines

For technical reasons, it is not possible to use your own computer for PowerPoint Presentations (PPP).

• Please bring your PPP on a USB memory stick to the symposium site.
• Name your PPP file as  LastName_FirstName_MISAM 2016.ppt

Your USB memory stick will be collected at the registration table on:
• Wednesday, June 15 between 3:30PM and 6:30PM
• Thursday, June 16 between 7:00AM and 8:00AM
• Friday, June 17 between 7:00AM and 7:30AM

Poster Presentation Guidelines

Set up of posters will be on:
•Wednesday, June 15 between 3:30PM and 6:30PM
•Thursday, June 16 between 7:00AM and 8:00AM

The poster boards will accommodate posters 80 inches long by 45 inches high.

The boards are compatible with pushpin mounting.

Authors need to be present at their poster for judging during the poster session:
Thursday, June 16 from 4:30PM till 6:00PM

Removal of the poster will be on:
Friday, June 17 after 1:00PM

The Montreal International Symposium on Angiogenesis and Metastasis aims at bringing  together scientists, clinicians and their trainees from cancer research institutions to present and discuss their recent, unpublished findings in the field of angiogenesis, metastasis and systemic cancer progression.

Indeed, angiogenesis and metastasis are two critical and interconnected processes, during which cancer becomes a progressive, systemic and lethal disease through the involvement of the vascular system.  Blood vessel networks that normally integrate the various physiological roles of individual cells, tissues and organs are hijacked and exploited by a growing tumour as a support and communication system, as well as conduit of dissemination. In the process, the intricate controls that govern homeostasis and formation of blood vessels and lymphatics become profoundly compromised, leading to unscheduled vascular expansion (tumour angiogenesis), abnormal blood vessel remodeling and development of a ‘parasitic’ tumour microcirculation. This process engages multiple populatios of regulatory and inflammatrory cells, fuels the disease progression, controls the distribution of, and response to, anticancer therapeutics, and shedding of cancer cells to systemic circulation, a precondition for establishment of secondary angiogenesis-dependent tumours in distant sites (metastasis). This ‘vascular fulcrum’ represents the ultimate threat and a formidable therapeutic challenge.

Symposium location: The Symposium will be held at Centre Mont Royal in downtown Montreal

Centre Mont-Royal
2200 Mansfield Street
Montreal Quebec, H3A 3R8
(514) 844-2000

Food Notes: Included in the registration fees are: light breakfasts, refreshment breaks, and buffet lunches.


Accommodations are not included in the symposium fees.

However, McGill University has negotiated preferential rates at Hotel Le Cantlie Suites which are available to those attending MISAM 2016 and a block of rooms has been reserved at the hotel at a reduced rate.

Reservations should be made directly with Hotel Le Cantlie Suites via an online registration link (available as of March 1st, 2016).
Online Reservations
The group code is 15166.


Hotel Le Cantlie Suites
1110 Sherbrooke Street West
Montreal, Quebec, H3A IG9 

To book within the MISAM 2016 block, please book through the online reservation link or contact:

Phone: 514 842-2000
Long Distance: 1- 888 CANTLIE (226-8543)

Hotel Le Cantlie Suites is located in the heart of downtown Montreal, on prestigious Sherbrooke Street. This charming boutique style hotel offers 256 very spacious guest rooms and 1 or 2 bedroom suites. All rooms offer the added convenience of fully equipped galley-style kitchenettes that include microwave and fridge, making the Hotel Le Cantlie Suites perfect for overnights, family travel and ideal for extended stays.

This hotel, with its central location, is surrounded by some of the city’s best restaurants, designer fashion shops, and renowned museums. In addition, the hotel is within walking distance to McGill University, the Centre Mont-Royal Convention Center, and Montreal’s extensive underground Metro system.

Hotel services include, rooftop heated swimming pool and sun deck (in season), a newly renovated fitness center, room service, dry cleaning service ($), business center and indoor valet parking ($).

At the fully licensed Le Mezz Restaurant/Bar, guests can enjoy Continental or American buffet breakfast as well as lunch and dinner à la carte. Also offered are: daily room service, wireless high speed Internet $, in-room complimentary coffee & tea, iron / ironing board / hair and dryer, telephone with remote access voice mail, individual climate control in every room, and dry cleaning service $.

It is recommended for out-of-town attendees to plan their travel well in advance to take advantage of good airfare and/or bus rates.

Travel Reminders:
• All travelers from USA and other countries require a valid passport to enter Canada.
• Be sure to confirm air and hotel arrangements at least 24 hours in advance of departure.
• As a reminder, never leave your wallet and passport unattended while traveling, and have Xerox copies of all identification and credit cards in case of theft of originals.

Ground Transportation from the Pierre Elliot Trudeau International Airport:
The Pierre Elliot Trudeau International Airport is 30 minutes away from downtown Montreal by rental car, shuttle or taxi.
Taxis are available at approximately $50 CAD.
For shuttle service, the Express Bus 747 is available. One-way fares are $7 CAD and two-way fares are $14 CAD (coins only, no bills). This bus is in service 24 hours a day, every day of the week. Tickets can be purchased at the Airport or directly from the driver. Reservations are not required. Please ask bus driver to drop you off at the Peel stop which is a 10 minute walk or 3 minute taxi ride to the Hotel Le Cantlie Suites.

To view more information, please visit the airport’s official website.

Via Rail Canada
VIA operates up to 497 trains weekly on 12,500 kilometers of track, and serves 450 communities across the country, from coast to coast and north to Hudson Bay. The nearest train stop is located about 1 mile (1.8 kilometers) from the meeting site. For more information or to buy tickets, please visit the Via Rail Canada website.

For anyone traveling from the United States, Amtrak has daily departures from multiple American cities to downtown Montreal. The train will stop 1 mile (1.8 kilometers) from the meeting site. To plan your trip please visit Amtrak’s site.

Montreal is accessible from various major expressways that lead directly to the city. Please remember to obey all Canadian road restrictions.  Parking at the hotel costs $25 CAD per day.

For more information about MISAM 2016 please contact:
Dr. Magdalena Maslowska at (514) 398-6268
Rosalind and Morris Goodman Cancer Research Centre
1160 Pine Avenue West, Room 602A
Montreal, Qc Canada H3A 1A3


Nicole Beauchemin, PhD
Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada

Nada Jabado, MD/PhD
Montreal Children’s Hospital Research Institute, McGill University, Montreal, QC, Canada

Janusz Rak, MD/PhD
Montreal Children’s Hospital Research Institute, McGill University, Montreal, QC, Canada


Pnina Brodt, PhD
McGill University Health Centre Research Institute, McGill University, Montreal, QC, Canada

Thomas Duchaine, PhD
Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada

Peter Siegel, PhD
Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada

Moshe Szyf, PhD
Pharmacology & Therapeutics Department, McGill University, Montreal, QC, Canada

Michael Witcher, PhD
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada


Project Manager

Magdalena Maslowska, PhD
Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada