David Dankort, PhD - Assistant Professor

Bellini Pavilion, room 2810
3649 Sir William Osler
Montréal, Québec
Canada H3G 0B1

Tel   (514) 398-2307
Fax  (514) 398-5369




Departments of Medicine and Oncology, McGill University
FRSQ Research Scholar
Associate Member, Goodman Cancer Research Centre


Cancer represents a failure of built-in protection mechanisms to quell rogue cells that have sustained oncogenic mutations. Paradoxically, many of the same mutated oncogenes that cause cancer also elicit a permanent growth arrest (senescence) or induce apoptotic cell death of primary cells: two such oncogenes are RAS and BRAF.  One research goal of my laboratory is to determine mechanistically how a tumour cell subverts these growth restraints leading to unbridled proliferation and ultimately malignancy.  We will use the power of mammalian genetics in ‘state-of-the-art’ genetically engineered mouse model and cell culture systems to define causative roles for RAS and BRAF-cooperating genes involved in lung cancer and melanoma development and progression.