May 3, 2018
NEOMED Institute partners with McGill University to identify small molecule inhibitors of a novel oncology target: Cut-Like Homeobox 1 (CUX1)
The NEOMED Institute announced today that it has entered into a development collaboration with McGill University. Dr. Kemal Payza, Senior Project Director at NEOMED Institute will collaborate with Dr. Alain Nepveu, Professor at the Goodman Cancer Research Centre and Departments of Oncology, Biochemistry and Medicine at McGill University, to discover new therapeutic small molecules to inhibit the protein target, Cut-Like Homeobox 1 (CUX1).

“I am delighted that we have added this new drug discovery project into NEOMED’s pipeline and I look forward to working with Dr. Nepveu on this very exciting target. Dr. Nepveu is a renowned expert on the DNA repair function of CUX1, a mechanism upon which RAS-driven cancer cells are acutely dependent for their survival. This is very important, because currently there is no treatment that targets RAS-driven tumours,” explains Dr. Payza.

“This academic/industrial collaboration that we have entered into with the NEOMED Institute will permit us to rapidly leverage our biological understanding of this important target to develop small molecule drug candidates. A drug capable of interfering with the ability of CUX1 to participate in DNA repair would target many types of cancers in which reactive oxygen species are produced as a consequence of mutation in a RAS gene or any oncogene that activates the RAS pathway; such activation is seen in 59% of pancreatic cancers and some 30% of human cancers overall,” adds Dr. Nepveu.

“This collaboration exemplifies, once again, the ability of NEOMED to deliver on its mission to help advance academic innovation and excellence by leveraging our industrial drug development experience and expertise. We look forward to collaborating with world-leading experts, like Dr. Nepveu and Dr. Zubaidah Ramdzan, to translate their science into therapeutic options for patients within the Canadian ecosystem,” concludes Donald Olds, President & CEO of NEOMED Institute.

About CUX1
Activation of the RAS pathway in cancer cells leads to higher production of reactive oxygen species, which cause DNA damage by oxidation. In turn, sustained DNA damage triggers cellular senescence. Cancer cells can adapt to such oxidative DNA damage by increasing their expression of CUX1, which stimulates the activities of two enzymes that repair oxidized bases in DNA.  Knocking down the CUX1 protein has been found to kill all cancer cells that have high levels of reactive oxygen species (ROS). Thus, small molecules that inhibit the ability of CUX1 to stimulate those critical DNA repair enzymes would be expected to provide therapeutic benefit to patients with RAS-driven cancers. While therapeutic approaches targeting various aspects of the DNA damage response are strategically important in cancer, direct inhibition of base excision repair enzymes can cause severe adverse effects on normal cells.  In contrast, CUX1 is not essential to normal cells, but is absolutely required for survival in situations of severe genotoxic stress such as that caused by reactive oxygen species in RAS-driven cancer cells or by DNA-damaging cancer treatments.  Thus, small molecules that inhibit the ability of CUX1 to stimulate base excision repair enzymes are expected to treat RAS-driven cancers with an improved therapeutic window.

 

May 2018
Trading lab coats for running shoes
Gabrielle Brewer, BSc’16, and Ritchie Truong will not show up to work at their respective labs on May 10. Instead, they will don colourful T-shirts, lace up their trainers, and join more than 1,000 other runners at the Défi Canderel, where they will co-captain the McGill Rosalind & Morris Goodman Cancer Research Centre (GCRC) contingent at the 2.5-km downtown run.

The two graduate students are currently recruiting lab mates to join them, and soliciting friends and family to pledge money for cancer research. Their goal is to attract at least 50 runners and raise more than the $5,922 that the GCRC student-led team raised last year. Visit here to show your support.

Members of the GCRC – whether they are trainees, administrators or PIs – lace up each year to show their support and appreciation for Défi Canderel. (Pictured here and below)
Brewer, who was also co-captain of the 2017 team, says her fundraising pitch is made easier by the fact that Défi Canderel divides its proceeds between the GCRC and the Institut du cancer de Montréal. “When you have a cause where you can tell people that it's directly coming back to the Centre that you work in, it's a lot easier to solicit donations.”

In fact, Brewer, a PhD student, receives funding directly from the Canderel proceeds, which facilitates her research into the process of breast cancer metastasis. She is working specifically on a breast cancer subtype that is not eligible for targeted therapies. Working with biomedical engineers, she tries to mimic the cancer without using animal subjects. “As one of my professors put it, we are working on making a better petri dish.”

Truong specializes in understanding the underlying pathways of autism and works as a research assistant at the GCRC in Dr. Nahum Sonenberg’s lab.

As a neuroscience researcher, he is not a direct recipient of Canderel funding but understands the importance of contributing to an event that supports his peers in cancer research.

Truong came to Canada seven years ago from Vietnam and found fundraising to be a cultural curiosity. He joined the Terry Fox Run when he was studying at McMaster University and volunteered last year for the Défi Canderel. He has quickly come to see how important fundraising is to medicine. “There are so many stories of people not finding the resources they need to do research.”
The Défi Canderel began in 1989, the year Susan Wener, wife of real estate developer and philanthropist Jonathan Wener, underwent treatment for cancer. “Naturally, we were devastated and terrified, looking for answers,” recalls Jonathan on the event’s website. “I was hoping that there was a piece of equipment we could buy. Her doctor responded that other than supporting her, the most powerful action would be to fund research. We organized a corporate run, the Défi Canderel.”

Since its inception, the run has raised nearly $14 million for Montreal’s two university cancer research centres. Susan Wener is healthy today, having survived two bouts with cancer.

Brewer says that receiving stipends like the one from Canderel enables labs at the GCRC to hire more students and provides those students with research opportunities, which, in turn, helps to build up a critical mass of researchers. “We're all working to find different information and sometimes being able to work on the same samples but with different questions can offer a huge insight.”

Brewer is confident that her fellow students will again bring lots of enthusiasm to the event. She says it helps that those who will potentially receive the funds are taking part in the activities. “We're all benefiting from the same thing that we’re putting our energy into.”

The two co-captains and GCRC colleagues are excited to show their support for cancer research in Montreal.

Show your support for the McGill GCRC student-led team here.

 

 

Goodman Cancer Research Centre

April 12, 2018
The Centre welcomes Fred Fox, brother of Terry Fox 
April 12, 1980 Terry Fox began his journey. Last night, on the anniversary of his run, the Centre was honoured to welcome his brother, Fred, and supporters of The Terry Fox Foundation on a tour of our Centre.

Goodman Cancer Research Centre

April 9, 2018
First ever Phil Gold Distinguished Lectureship in Cancer Research
It was a special evening, with Dr. Scott W. Lowe of Memorial Sloan Kettering, as the inaugural speaker at the Phil Gold Distinguished Lectureship in Cancer Research, named for the first director of the McGill Cancer Centre in 1978. The GCRC was honoured to have him and his wife in attendance. 


March 21, 2018
Shawn McGuirk awarded Scarlet Key Award
Shawn McGuirk has received the McGill University Scarlet Key Award by principal Suzanne Fortier. He was honoured for his contributions to Science and Policy Exchange.


March 16, 2018
Tina Gruosso and Vanessa Sung win Principal's Prize
Congratulations to Tina Gruosso and Vanessa Sung on winning the McGill University Principal’s Prize for Public Engagement in media.


February 2018
Save the date - 5th Goodman Cancer Research Centre Gala

World-class collaboration. Join us on June 6, 2018 to support and celebrate our internationally renowned researchers in their quest to improve the lives of cancer patients through translational research and clinical partnerships across Quebec.

Theme: The Lung Cancer Network: Collaborate to Cure

The 2018 Gala celebrates the establishment of a large, innovative Lung Cancer Network that will bring together the greatest minds, big data, the best technology and the highest quality research to tackle the challenges of lung cancer and metastatic disease.
At the GCRC, we know that the key to making strides in treating cancer is close collaboration among scientists, clinicians and their patients. Our goal is for hospitals across Montreal to partner with the GCRC in a united mission to double the number of lung cancer survivors in Quebec over the next 10 years.

For more information: http://mcgillgcrcgala.com/


January 24, 2018
Student recruitment event
For the second year in a row, potential students came from around the world to meet and mingle with many of our world-class researchers. The event is organized to encourage students to pursue their research at the GCRC.

For more information, click here.


Dr. Nahum Sonenberg, Goodman Cancer Research Centre

January 23, 2018
Nahum Sonenberg awarded CIHR grant
Congratulations to Dr. Nahum Sonenberg, a top Canadian cancer researcher who is poised to use the knowledge he’s gained studying cancer at the Centre, to understand Alzheimer’s disease. Announced today, he will receive a $500,000 grant from the Canadian Institute for Cancer Research, as part of a $2.5 million investment by the Government of Canada into dementia research.


January 4, 2018
Why supporting basic research is so important.

Tina is a postdoctoral researcher at McGill University and VP of the non-profit Science & Policy Exchange, which launched the #Students4thereport campaign in support of basic research and the review of federal support for science.

Link to article


November 2017
Mark your calendar: December 1 - Hugs for Hope
Started by a group of volunteers at the Goodman in 2013, Hugs for Hope is a non-profit organization which makes handmade pillow blankets for cancer patients. To date, over 500 blankets have been donated to patients at the Jewish General Hospital, St-Mary's Hospital and Children's Hospital.
On December 1, between 11:30 and 2:00 p.m. volunteers will be selling blankets and baked goods at the McIntyre Medical Sciences Building. Join them, and help continue sharing warmth and support to those fighting cancer.
 

November 2017
Dr. Morag Park receives Robert L. Noble Prize, as awarded by the Canadian Cancer Society
At a ceremony in Toronto, Dr. Morag Park received the Robert L. Noble prize, as awarded by the Canadian Cancer Society. "The Canadian Cancer Society brings together the best scientific minds to share knowledge and discoveries. This is what leads to cancer breakthroughs", said Dr. Park. 
The prize is given for outstanding achievements in basic biomedical cancer research. It honours Dr Noble, an esteemed Canadian investigator whose research in the 1950s led to the discovery of vinblastine, a widely used anticancer drug.The award comes with a $20,000 contribution to the recipient’s research program.
 

November 2017
Goodman Cancer Research Centre promotes Lung Cancer Awareness Month 
Lung cancer kills more Canadians each year than breast, prostate and colon cancer combined. As part of a new video series, the Goodman will introduce a scientist and their research each month. Click here to meet Dr. Logan Walsh, a lung cancer researcher.

October 2017
New triple negative breast cancer study published
Congratulations to Paul Savage, an M.D./Ph.D. student in Dr. Morag Park’s lab, on his recent paper “A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer.”
Appearing in Cell Reports, the paper focuses on research surrounding triple negative breast cancer, a highly aggressive form of the disease which tends to relapse within the first three years after diagnosis.
With collaborations from surgeons to lab technicians, the study aimed to, “see whether diversity of tumors can be targeted by going after specific cells, known as cancer stem cells,” explains Mr. Savage.
 

October 2017
New breast cancer study could lead to more accurate predictions of cancer development
New research published in Genes and Development by Dr. Luke McCaffrey and his lab could lead to more accurate predictions of breast cancer development. Previously, it was thought that carcinoma tumours were caused by cells shedding to fill the middle of the mammary duct in a single step, but in fact it was found that there are a number of discrete steps that define the progression that were previously not known.

October 2017
Goodman Cancer Research Centre receives $20,000 donation from La Vie en Rose
Once again, La Vie en Rose has generously donated $20,000 to breast cancer research at the Goodman Cancer Research Centre, at McGill University. The announcement, made late last week, is part of a larger giving campaign by La Vie en Rose called, Le Confort pour la Cause (Comfort for the Cause), where the company donates a total of $100,000 each year to organizations across the country.

October 2017
Drs. Peter Siegel and Julie St-Pierre release new breast cancer study
Drs. Peter Siegel and Julie St-Pierre have released their new breast cancer study revealing new pathways for metastasis.
Their paper, published in Cell Metabolism, likens cell travel to when driving to a remote destination that is accessible by only one road, if this is blocked you are stuck. In contrast, if you are travelling in the city and discover that your preferred route is blocked, you can adjust and take another path to your destination. That is what is happening here – if breast cancer cells are restricted to one metabolic pathway they are not able to spread as effectively as cancer cells that engage multiple pathways.

October 2017
Dr. Phil Gold honoured
The Canadian Friends of Hebrew University has developed the Einstein Legacy Project, a global initiative to inspire the next generation of brilliant minds and bring fresh thinking to the problems facing our planet.
Included in their list of 100 of the world’s foremost thought leaders is Dr. Phil Gold, the founder of the McGill University cancer research centre.

October 2017
CIHR celebrates Canada's 150
As part of Canada's 150 celebration, the Canadian Institutes of Health Research asked researchers how and why they are changing lives - Dr. Nicole Beauchemin answered.

September 2017
Jose Teodoro receives Movember Foundation grant
Congratulations to Dr. Jose Teodoro on being one of twelve to receive a grant from the Movember Foundation, as selected by Prostate Cancer Canada and the Movember Foundation Canada.

September 2017
Michel Tremblay wins McLaughlin Medal
Congratulations to Dr. Michel Tremblay who has been awarded the McLaughlin Medal by the Royal Society of Canada for his outstanding work in cancer research. The medal – given out annually since 1979 – is presented to a researcher who has demonstrated sustained excellence in the medical sciences. 

Dr. Tremblay becomes the third member of the Goodman to win this prestigious medal, with Drs. Nahum Sonenberg and Philippe Gros having won it in 2013 and 2014, respectively.

September 2017
Barry Pascal named co-chair of 2018 Gala
On September 14, Dr. Morag Park raised a glass and launched the official kick-off to the 2018 Gala - taking place on June 6, 2018.
Surrounded by generous supporters, volunteers and Goodman researchers, Barry Pascal was introduced as one of the co-chairs for the upcoming gala, and we couldn't be more honoured to have him.

September 2017
Congratulations to Dr. Jerry Pelletier on being named a Fellow of the Royal Society of Canada!
Dr. Jerry Pelletier has been named a Fellow by the Royal Society of Canada (RSC). He joins eight other researchers from McGill who were also inducted into the RSC this year.
With over 2,000 Fellows, inductees are selected by their peers for outstanding contributions to the natural and social sciences, arts and humanities.

August 2017
Drs. Vincent Giguère and Étienne Audet-Walsh research selected as Editor's Choice
New research on prostate cancer from Drs. Vincent Giguère and Étienne Audet-Walsh was given high praise from Genes & Development when their recent paper was selected as the Editor's Choice.

August 2017
Dr. Nahum Sonenberg profiled in Proceedings of the National Academy of Sciences
The distinguished life and career of renowned researcher, Dr. Nahum Sonenberg, was recently featured in the early edition of the Proceedings of the National Academy of Sciences of the United States of America. Read his inspiring story 

August 2017
Korean delegation visits Goodman Cancer Research Centre
Scientists from Korea visited the Goodman as part of the Canada-Korea Conference on Science and Technology. Former centre director, Dr. Michel Tremblay, spoke with the delegation about the McGill Stem Cell and Regenerative Medicine network, which includes the research centres at the MUHC, Jewish General Hospital and McGill University.

August 2017
University of Cyprus visits Goodman Cancer Research Centre
On August 8, The Goodman welcomed medical students from the University Of Cyprus, where they saw first-hand the amazing things that are happening at the Rosalind & Morris Goodman Cancer Research Centre, McGill University.
The students are in Montreal as part of a one-week delegation visiting the Steinberg Centre for Simulation & Interactive Learning at McGill University.

Goodman Cancer Research Centre

August 2017
Welcome Dr. Daniela Quail and Dr. Logan Walsh
This month the Goodman Cancer Research Centre welcomed two new members, Dr. Daniela Quail and Dr. Logan Walsh. The dynamic pair join the Centre from New York City, having worked at Memorial Sloan Kettering Cancer Center for the last five years.
Dr. Quail will focus on brain, breast and lung cancers, while Dr. Walsh's centre of interest will primarily be lung cancer, with additional interests in ovarian, liver and breast cancer.

Goodman Cancer Research Centre

May 2017
Congratulations to GCRC Researchers who received CIHR Project Grants
Congratulations to Drs. Thomas Duchaine, Arnim Pause, Peter Siegel and Ian Watson, recipients of CIHR Project Grants.
The Project Grant program is designed to capture ideas with the greatest potential to advance health-related fundamental or applied knowledge, health research, health care, health systems, and health outcomes. It supports projects with a specific purpose and a defined endpoint. The best ideas may stem from new, incremental, innovative, and/or high-risk lines of inquiry or knowledge translation approaches.


May 2017
Dr. Michel L Tremblay, recipient of the CIHR Bridge Grant
The GCRC is happy to congratulate Dr. Michel L Tremblay for this achievement!


Dr. Vincent Giguère, Goodman Cancer Research Centre

May 2017
Dr. Vincent Giguère awarded a Canadian Cancer Society (CSS) Innovation Grant
CSS Innovation Grants support innovative, creative problem solving in cancer research. The GCRC is happy to congratulate Dr. Giguère for the success of his project entitled,"A nuclear mTOR/DNA-PK complex: interaction with chromatin and its impact on prostate cancer."  Read a summary of this research project.


Dr. Arnim Pause, Goodman Cancer Research Centre

May 2017
Congratulations to Dr. Arnim Pause- recipient of a CCSRI Innovation to Impact Grant
This grant has been designed to support the further development of successful findings based on the goals originally explored through a CCSRI Innovation Grant. Dr. Pause received this grant in support of his research project entitled: "Haploinsufficient loss of ESCRT components as new drivers of cancer." Read a summary of the study


Dr. Morag Park, Goodman Cancer Research Centre

March 8, 2017
Dr. Morag Park awarded the prestigious Robert L. Noble Prize
Dr. Morag Park, Director of the Goodman Cancer Research Centre and Professor of Biochemistry, Medicine and Oncology, is the recipient of the Canadian Cancer Society 2017 Robert L. Noble Prize. 
The Canadian Cancer Society has honoured Dr. Park for her role as a leader in Canadian cancer research, being widely recognized for identifying key events in cancer development and the importance of a tumour’s surroundings for cancer growth, as well as her exceptional leadership in establishing national cancer research strategies.
Read the entire Med e-News article
Read the Canadian Cancer Society announcement


Dr. Nahum Sonenberg, Goodman Cancer Research Centre

March 3, 2017
Canada Foundation for Innovation awards McGill researchers over $4.5 million for state-of-the-art research equipment and facilities.
The Foundation for Innovation was established to support Canada’s top researchers to innovate, as well as to attract and retain top research talent, by giving them access to cutting-edge research equipment, laboratories and tools.
The GCRC proudly congratulates Dr. Nahum Sonenberg for receiving this important funding.
Read more


March 3, 2017
Congratulations Dr. Nicole Beauchemin for her role in the collaborative project that was awarded Québec Science’s “Découverte de l’année 2016 – Prix du public”

Professor Sylvain Martel of École Polytechnique de Montreal’s Nanorobotics laboratory has pioneered an approach using special bacteria that can be directed by a magnetic field to deliver chemotherapy directly to the site of tumors, reducing side-effects.
With the support of a team of co-investigators from McGill University (Drs. Te Vuong, Gerald Batist, Maryam Tabrizian, Nicole Beauchemin, Danuta Radzioch), the Université de Montréal (Dr. Louis Gaboury, Dr. Michel Lafleur), and with the support of a generous grant from CQDM, Dr. Martel and his team have demonstrated proof-of- concept as well as efficacy and lack of toxicity of this new technique using primary colorectal cancer cells.
This novel approach holds significant promise for improving cancer targeting with chemotherapy.

Read Québec Science Article
Read the Med e-News Article


March 3, 2017
This day marks the 25th anniversary of the Tremblay Lab!
Since 1992, Dr. Tremblay and his lab members have helped put the GCRC on the global map of discovery and innovation.
Over 60 researchers, students, postdoctoral fellows and supporting staff have been or are currently committed to the Tremblay Lab research projects. New discoveries are on the horizon for the Tremblay Lab - that will lead to the development of novel treatments for a broad range of human diseases including diabetes, obesity, spinal cord injury and infectious diseases as well as in diverse cancers.
Congratulations to Dr. Tremblay and all his lab members, past and present!


Dr. Jose Teodoro, Goodman Cancer Research Centre

March 3, 2017
The Teodoro Lab celebrates 10 Years!
It has been already 10 years since the Teodoro laboratory started its adventure. Our lab has had many achievements during this decade, including contributions to at least 20 papers and two PhD thesis defenses. We have also enriched the education of many undergraduate students by training them in proper research methods. We have a friendly working environment, which is led by an expert scientist who encourages us and helps us take control of our own future. We are hoping that our lab will continue to investigate exciting new research areas for many more years to come.
Teodoro Lab Members


February 2017
Congratulations to Dr. Jose Teodoro and his team for their latest publication in Cell Reports
This article reports that 53BP1 is a mitotic APC/C substrate and an interphase inhibitor. 53BP1 silencing leads to a hyperactive APC/C, resulting in cell cycle defects and sensitivity to mitotic poisons. This helps to explain observations that 53BP1 null mice display aneuploidy and cancer susceptibility.
Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress
Thomas J. Kucharski, Paul E. Minshall, Mohamed Moustafa-Kamal, Andrew S. Turnell, Jose G. Teodoro


The Journal of Biological Chemistry, Michel L Tremblay

January 20, 2017
GCRC on the Front Cover of Research
The cover page from the Journal of Biological Chemistry 292, 786-801 of January 20, 2017 was generated by Dr. Alfonso Martinez de la Cruz (BioGune Institute in Bilbao, Spain) and Dr. Noriko Uetani (Tremblay’s lab GCRC). It represents the first structure of the CNNM2 CBS domain with the protein tyrosine phosphatase PRL-1. The complex is shown over a stain section of human breast cancer. The importance of this complex relates to its almost universal contribution in sustaining the high metabolism needed by cancer cells during proliferation and specially in the process of metastasis. Knowing the intimate structure of this complex allows us to move ahead in the development of exquisitely sensitive small molecule disruptors as a new class of therapeutics in many types of human cancers.  Read more

The Journal of Biological Chemistry, Michel L Tremblay

January 20, 2017
GCRC on the Front Cover of Research
The cover page from the Journal of Biological Chemistry 292, 786-801 of January 20, 2017 was generated by Dr. Alfonso Martinez de la Cruz (BioGune Institute in Bilbao, Spain) and Dr. Noriko Uetani (Tremblay’s lab GCRC). It represents the first structure of the CNNM2 CBS domain with the protein tyrosine phosphatase PRL-1. The complex is shown over a stain section of human breast cancer. The importance of this complex relates to its almost universal contribution in sustaining the high metabolism needed by cancer cells during proliferation and specially in the process of metastasis. Knowing the intimate structure of this complex allows us to move ahead in the development of exquisitely sensitive small molecule disruptors as a new class of therapeutics in many types of human cancers.  Read more


Dr. William Muller, Goodman Cancer Research Centre

December 2, 2016
The Honorable Kirsty Duncan, Minister of Science, announced 203 new and renewed Canada Research Chairs (CRC) at universities across Canada. Congratuations Dr. William Muller, who received the Tier 1 Renewal – Canada Research Chair in Molecular Oncology
Dr. William Muller's work to date has focused on elucidating the molecular mechanism by which oncogenes - genes that turn normal cells into tumorous cells - are involved in inducing breast cancer in a murine system. He has also developed a large series of transgenic animals that have allowed him to address the effects of various signalling and growth factors in the development of malignancy. As Canada Research Chair in Molecular Oncology, Dr. Muller plans to continue to investigate the interrelationship between distinct hormone, growth factor and signalling pathways in the induction of breast cancer. Read more


November 16, 2016
Unique mechanism for vinca site tubulin binding drug DZ-2384 without neurotoxicity – a major advancement for microtubule targeting agents.
In 2013, Diazon Pharmaceuticals teamed up with The Laboratory for Therapeutic Development (LTD) to identify the mechanism of action of a potential new anticancer agent called DZ-2384.  Members of the LTD, Dr. Joseph Tcherkezian, Cynthia Bernier, Dr. Yannève Rolland and Claude Godbout carried out functional genomic screens to identify the anti-mitotic mechanism.  They then went on to characterize its unique effects on microtubule dynamics compared with other anti-mitotics as well as to determine the activity of the compound in several mouse tumor models.  The study, published in Science Translational Medicine, was led by Drs. Anne Roulston and Gordon Shore along with Dr. Gary Brouhard Dept of Biology, and includes as collaborators GCRC members Drs. Peter Siegel and George Zogopoulos as well as several international labs.In 2013, Diazon Pharmaceuticals teamed up with The Laboratory for Therapeutic Development (LTD) to identify the mechanism of action of a potential new anticancer agent called DZ-2384.  Members of the LTD, Dr. Joseph Tcherkezian, Cynthia Bernier, Dr. Yannève Rolland and Claude Godbout carried out functional genomic screens to identify the anti-mitotic mechanism.  They then went on to characterize its unique effects on microtubule dynamics compared with other anti-mitotics as well as to determine the activity of the compound in several mouse tumor models.  The study, published in Science Translational Medicine, was led by Drs. Anne Roulston and Gordon Shore along with Dr. Gary Brouhard Dept of Biology, and includes as collaborators GCRC members Drs. Peter Siegel and George Zogopoulos as well as several international labs.   Read more


The Goodman Cancer Student Society & the Biochemistry Graduate Student Society
Career Development Day
Learn from the experts 1-4 pm
Professional development workshops for the skills you need
Career Planning: CV building, Individual career planning, Professional communication
Transferable Skills: Statistics, Academic job search, Public speaking
Research skills: High thru-put screens, Clinical samples, Big data

Spotlight 4-5pm
Emily Bell, PhD

Manager / Professional skills specialist | Desjardins Centre for Advanced Training of the RI-MUHC
“Preparing for a career after graduate school: what to do and when?”

“Speed dating” with the pros 5-8pm
Network with professionals currently employed across the biomedical industry for a “speed dating” style wine & cheese.
Features mostly McGill alumni!

Date: Friday, November 18, 2016 
Location: Goodman Cancer Research Centre and the Bellini Complex  Detals and registration


Friday, October 21st, 2016
Dr. Jerry Pelletier | New member of McGill's Quarter Century Club
Congratulations to Dr. Jerry Pelletier on his 25 years of service at McGill University.   


Friday, September 23th, 2016
New mechanism for spread of breast cancer identified
Congratulations to Dr. Charles Rajadurai and Dr. Morag Park on their study, in collaboration with the Massachusetts Institute of Technology, published recently in the Journal of Cell Biology that identifiies a new mechanism for the metastatic spread of breast cancer involving the enzyme SHIP2. The discovery is of particular importance given that SHIP2 is a drug target for which new molecular inhibitors are already in development.   Read more


Wednesday, September 21th, 2016
The Tumor Microenvironment- Methods and Protocols
Congratulations to Drs Nicole Beauchemin and Josie Ursini-Siegel on the launch of their new book that features cutting-edge methods and protocols for tumor microenvironment research.   Read more


Monday, September 19th, 2016
The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism
Congratulations Graduate Student Said Izreig from the labs of Thomas Duchaine and Rusty Jones for his latest paper in Cell Reports.   Read more


Friday, September 16th, 2016
Fledgling network brings together McGill’s stem cell researchers
This article, featuring Professor Michel L Tremblay,  highlights what the McGill University scientific community is doing in stem cell research.   Read more


Sunday, September 18th, 2016
Join us for the Terry Fox Run
To join the team or donate to a runner, please visit the GCRC Foxtrotters team page  Read more


Monday, August 15th, 2016
Legions of nanorobots target cancerous tumours with precision
Researchers from Polytechnique Montréal, Université de Montréal, the Goodman Cancer Research Centre and McGill University have just achieved a spectacular breakthrough in cancer research. They have developed new nanorobotic agents capable of navigating through the bloodstream to administer a drug with precision by specifically targeting the active cancerous cells of tumours. This way of injecting medication ensures the optimal targeting of a tumour and avoids jeopardizing the integrity of organs and surrounding healthy tissues. As a result, the drug dosage that is highly toxic for the human organism could be significantly reduced.  Read more


cihr-irsc

July 2016
Congratulations to GCRC researchers who received CIHR 2016 Project Grants
Peter Siegel:  "Metabolic Adaptations During Breast Cancer Metastasis"
Julie St-Pierre"ShcA-coupled receptor tyrosine kinase signaling exposes PGC1a-dependent metabolic vulnerabilities in cancer progression and therapy"
Visit the CIHR website for project details


cihr-irsc

July  2016
Congratulations to GCRC researchers who received CIHR 2016 Foundation Scheme grants
Philippe Gros; "Genetic analysis of susceptibility to infections and to inflammation"
William Muller: "Oncogene-mediated signal transduction in transgenic mouse models of human breast cancer"
Jerry Pelletier:  "Targeting Deregulated Translational Control in Cancer"
Nahum Sonenberg: "Investigating mRNA translational control in the quest to cure human disease." 
Visit the CIHR website for project details


Tuesday, June 12th, 2016
Congratulations to Dr. Vincent Giguère and trainee Geneviève Deblois, for their recent publication in Nature Communications
Despite the initial benefits of treating HER2-amplified breast cancer patients with the tyrosine kinase inhibitor lapatinib, resistance inevitably develops. Geneviève Deblois, a trainee in Dr. Vincent Giguère’s group, assembled a team of researchers from six different laboratories affiliated with the GCRC to find the mechanisms leading to resistance to this drug in HER-2 positive breast cancer.  Read More   Link to Publication


Dr. Dr. Philippe Gros, Goodman Cancer Research Centre

Thursday, June 30th, 2016
Congratulations to Dr. Philippe Gros for his appointment to the Order of Canada.
Established in 1967 by Her Majesty Queen Elizabeth II, the Order of Canada is the cornerstone of the Canadian Honours System, and recognizes outstanding achievement, dedication to the community and service to the nation.

Philippe Gros, O.C. received this honour for his pioneering use of molecular genetics to identify risk factors in a range of conditions, including infectious diseases and cancer, and for his leadership in the health sciences.   Article in the McGill Reporter


Monday, June 6th, 2016
Dr. Pelletier's publication 'Using CRISPR to validate drug-target interactions' is featured on the cover of Cell Reports
Precise genome engineering for validation of drug mechanism. Chu et al. use CRISPR/Cas9 to demonstrate that inhibition of eukaryotic initiation factor (eIF) 4A by rocaglates is responsible for their in vivo anti-neoplastic activity. The gears represent mechanism of action with the laser denoting precise targeting of a critical component, eIF4A.  Artwork by Dr. Noriko Uetani.

Article


Monday, June 6th, 2016
Dr. Philip Branton receives the McGill University Medal for Exceptional Academic Achievement
Established in 2009, the McGill University Medal for Exceptional Academic Achievement is awarded to retired members of McGill’s academic staff who are uniquely deserving in light of their exceptional contributions to their discipline, to the University and to society at large.

The Goodman Cancer Research Centre is proud to congratulate Dr. Branton for his achievement.

Read the McGill Reporter article.


Sunday, June 5th, 2016
Three of the Centre’s renowned researchers were presented with prestigious awards in recognition of their outstanding work.
Congratulations to GCRC researchers who were honoured at the 4th biennial Goodman Gala:
Dr. Nicole Beauchemin, who was presented with the Limelight Award for her commitment to colon cancer research and her dedication to the Centre’s public outreach forums.
Dr. Nahum Sonenberg, who was presented with the Leadership Impact Award for his longstanding leadership in cancer research. Dr. Sonenberg was the 2014 recipient of the prestigious Wolf Prize, generally regarded as a precursor to the Nobel Prize.
Dr. Ian Watson, who was presented with the Future is Bright Award for his leadership in melanoma genomics research.

 


Sunday, June 5th, 2016
Goodman Cancer Research Gala raises $2.1 million
T
he 4th Goodman Cancer Research Gala has raised more than $2.1 million to fund foundational research, more effective diagnostic tools and the development of new treatments and therapies for cancer patients.

Read the Med e-News article.


Dr. Luke McCaffrey, Goodman Cancer Research Centre

May 20, 2016
Dr. Luke McCaffrey receives tenure
The Goodman Cancer Research Centre is proud to congratulate Associate Professor Luke McCaffrey for achieving tenure and promotion.   

 


Dr. Philip Branton, Goodman Cancer Research Centre

Friday, May 27th, 2016
A symposium in honour of Professor Philip E. Branton
Friday, May 27th, 2016 | 13:00 - 17:45
Sponsored by the Depts. of Biochemistry and Oncology and the Goodman Cancer Research Centre
"What we have learned about cancer over the past 40 years, and what we still do not know"
DateFriday, May 27th, 2016 | 13:00 -  17:45 
Location: McGill University Faculty Club                    Poster


Tuesday, May 10, 2016
Wear your favourite jeans on National Denim Day 2016
On Tuesday, May 10th, wear your favourite jeans and the CURE Foundation’s pink ribbon in support of National Denim Day, a fundraiser for breast cancer research.

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Thursday, May 5th, 2016
Defi Canderel 2016
On Thursday May 5th, 2016 More than 1000 SUPERHEROES will tighten their laces & run in the streets of MOntreal to join the fight against cancer!

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First authors of the study, David Papadopoli (l) of the St-Pierre lab and Etienne Audet-Walsh of the Giguère lab

January 15, 2016
GCRC Researchers uncover mechanism that makes cancer cells more susceptible to treatment
In a new study published in the journal Cell Reports, researchers at the Goodman Cancer Research Centre have uncovered a potential mechanism to make cancer cells more sensitive to chemotherapy.
Read the Med e-News Article


Monday, November 30, 2015
Dr. Nicole Beauchemin and Dr. Jerry Pelletier honoured at the 5th annual Gerald Bronfman Centre Symposium
The GCRC is proud to congratulate Dr. Nicole Beauchemin upon receiving the Lifetime Achievement Award
and Dr. Jerry Pelletier for receiving the Award for Research and Clinical Service at the 5th annual Gerald Bronfman Centre Symposium and Awards Ceremony.

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Tuesday November 24th, 2015
Scientific Symposium Celebrating the 50th Anniversary Discovery of Carcinoembryonic antigen (CEA) Honouring Dr. Phil Gold and Dr. Samuel Freedman
 

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In conversation with Dr. Phil Gold, pioneering cancer researcher


Monday, November 2, 2015
Dr. Park and Dr. Sonenberg honoured by CCRA
Two McGill researchers have been recognized for their efforts in ongoing fight against cancer. As announced earlier today, the Canadian Cancer Research Alliance (CCRA) has honoured four researchers with its annual awards. Morag Park has earned the CCRA’s award for Exceptional Leadership in Cancer Research while Nahum Sonenberg won the Outstanding Achievements in Cancer Research award. The official presentations will be made during the Canadian Cancer Research Conference on Nov. 8 and 9.
Article
 


Dr. Nahum Sonenberg, Goodman Cancer Research Centre

October 19, 2015
Dr. Nahum Sonenberg elected to the National Academy of Medicine
On October 19, the National Academy of Medicine, formerly the Institute of Medicine, announced the election of 70 regular members and 10 international members during its annual meeting. Among the inductees is Dr. Nahum Sonenberg, who was elected as an international member.
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September 25, 2015
Congratulations GCRC Foxtrotters!
This year, the GCRC Foxtrotters raised $13,700 for the 35th Annual Terry Fox Run!
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September 18, 2015
GCRC Receives $5.3M from the Terry Fox Foundation
In this 35th anniversary year of the Terry Fox Marathon of Hope, the GCRC TFRI team, led by Dr. Vincent Giguère, has been awarded $5.3 million to better understand how metabolic processes and pathways contribute to the growth and survival of cancer cells.
Read more

 


September 11, 2015
Julianna Blagih Chosen as Star-of-the-Month for July by FRQS
The GCRC is very proud to congratulate Julianna Blagih, of Dr. Jones' Laboratory, for receiving this honour, as a result of her
award-winning publication entitled, "The Energy Sensor AMPK Regulates T Cell and Metabolic Adaptation Effector Responses In Vivo."
Read more

 


Goodman Cancer Research Centre, Walk for Montreal, MUHC, Smart Palate Cookbook

June 22, 2015
Walk for Montreal
The student team from the GCRC along with Dr. Morag Park, Director and Dr. Peter Siegel, Associate Director joined the Walk for Montreal  with the Faculty of Medicine.
Staff and volunteers had a great afternoon listening to music, watching the inauguration ceremony and best of all, selling The Smart Palate cookbook to participants of the walk at the MUHC Glen site.
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March 26, 2015
Thomas Duchaine wins prestigious HFSPO research grant
Thomas Duchaine of the Department of Biochemistry at the Goodman Cancer Research Centre has been named the recipient of a prestigious and highly competitive Program Grant from the International Human Frontier Science Program Organization (HFSPO).
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September 26, 2014
Two Faculty Members are published in Nature Reviews Cancer
Dr. Morag Park and the Goodman Cancer Research Centre community would like to congratulate Dr. Alain Nepveu   and Dr. Thomas Duchaine for their recent publications in Nature Reviews Cancer.
Publication


August 26, 2014
The GCRC Mourns the Loss of Rosalind Goodman
The Rosalind and Morris Goodman Cancer Centre and the McGill University community are mourning the passing of Rosalind Goodman, a devoted alumna, generous philanthropist, and tireless volunteer, who committed herself to energizing cancer research activities at McGill and to educating others about the disease.
Read more


June 30, 2014
Jonathan Wener is Honoured at the National Assembly
The Goodman Cancer Research Centre is happy to congratulate Jonathan Wener for the Declaration of the National Assembly in celebration of the 25th edition of Défi Canderel.

National Assembly Declaration
Défi Canderel website                   Read more


June 30, 2014
Dr. Phil Branton Named to The Order of Canada
On Monday, June 30th, the  Governor General of Canada, David Johnson announced the newly appointed members to the Order of Canada.
Among the recipients is Dr. Philip Branton, O.C. (Officer of the Order of Canada) for his leadership in the development of a national cancer research framework, and for his contributions to our understanding of tumour viruses and cell division regulation.
Govenor General of Canada News Release.
McGill Reporter News Release.


Dr. Julie St. Pierre, Goodman Cancer Research Centre

June 26, 2014
Dr. Julie St-Pierre Winner of The Maude Abbott Prize
The Goodman Cancer Research Centre (GCRC) is delighted to announce that Dr. Julie St. Pierre has won the 2014 Maude Abbott Prize, awarded by the Faculty of Medicine, McGill University.
Established in 2010, the Maude Abbott Prize recognizes outstanding female Faculty Members who excel in Education, Research or Administration with a focus at the early career stage.
The faculty, staff and trainees of the GCRC extend their heartfelt congratulations to Dr. St-Pierre for receiving this honour.

 


Dr. Julie St. Pierre, Goodman Cancer Research Centre

June 26, 2014
How a Test can Help Treat each Cancer Patient the Right Way
The GCRC Breast Cancer Start-Up Challenge team, ProVivoX, has launched its crowdfunding initiative. Its goal is to create a test that will help cancer patients minimize undesired side effects of chemotherapy and maximize their quality of life. This innovative prognostic cancer test wil better predict patient survival and therapy response, key factors in personalized medicine. Visit the ProVivoX website to learn more about this initiative.

 


Young Women in Biology Planting the Seeds of Science

March 24, 2014
Young Women in Bio
This year, the Goodman Cancer Research Centre paired up with the Young Woman in Bio – Greater Montreal Chapter to help introduce young girls to the importance of studying science.
On March 24, 2014 girls from Sacred Heart School of Montreal visited the Goodman Cancer Research Centre to learn about the important place women have in science, the basic cancer research done at the Centre, the many fascinating discoveries and, of course, the potential future careers. A dedicated group of graduate students took their time to meet with the students , show them research laboratories, and involved them in scientific experiments. Everyone had a blast. The day finished with a pizza lunch which provided an opportunity to answer many questions. Many thanks to our young scientists Alyssa (PhD), Juliana (PhD), Sylvia (MSc), Ruby (PhD), Laura (MSc) and Azadeh (RA) for being great mentors.


Goodman Cancer Research Centre, La Vie en Rose

February 3, 2014
La Vie en Rose Donates $12,500 to the GCRC
The GCRC is very grateful to La Vie en Rose for its generous donation to basic cancer research.
La Vie en Rose, through its Roses of Hope Foundation, made 9 donations across Canada totalling $60,000 in time for World Cancer Day.

Photo
Press Release


Dr. Nahum Sonenberg, Goodman Cancer Research Centre

Friday, January 17, 2014
2014 Wolf Prize Awarded to Dr. Nahum Sonenberg
It is with great honor and pride that the Goodman Cancer Research Centre recognizes an incredible achievement of one of our own scientists, Dr. Nahum Sonenberg, who is a co-recipient of the 2014 Wolf Prize in Medicine.

This prestigious award has been held by many renowned scientists, who have gone on to be recipients of the Nobel Prize. Dr. Sonenberg shares the prize with two American Scientists for his seminal contributions to the field of mRNA translation, which has important implications for a variety of pathological conditions, including cancer. In fact, the biochemical pathways that have been worked out in Dr. Sonenberg’s laboratory have paved the way for numerous anti-cancer agents that are currently being developed for the management of this disease.

We extend our congratulations to Nahum on this well-deserved recognition.

CBC News Article
Times of Israel Article
McGill Reporter Article


November 12, 2013
Dr. Michel L. Tremblay Awarded The Prix Armand-Frappier 2013
We are proud to announce that Dr. Michel L. Tremblay has received the prestigious prix du Québec, Armand-Frappier award.

Each year, the government attributes five prix du Québec awards in the scientific field and six in the cultural field. The purpose of this tribute is to recognize the career of women and men who have demonstrated a passion for their calling. Individuals who have stood out by their creative or innovative spirit and whose work has contributed to the influence of Québec around the world and to the evolution of Québec society in their respective fields.

Please join us in congratulating our esteemed colleague for his outstanding achievements and its acknowledgement through the receipt of this award.
Michel continues to inspire and set an example of scientific excellence for all of us at the Goodman Cancer Research Centre.


Dr. Nahum Sonenberg, Goodman Cancer Research Centre

September 6, 2013
Nahum Sonenberg Awarded The Mclaughlin Medal from The Royal Society of Canada
We are proud to announce that The Royal Society of Canada has awarded the prestigious gold plated silver McLaughlin Medal to Dr. Sonenberg on September 6, 2013. The Royal Society of Canada is the senior national academy of distinguished Canadian scholars, artists and scientists. The McLaughlin Medal honors sustained excellence in medical science. We are delighted that Dr. Nahum Sonenberg’s work on the control of protein synthesis in cancer, autism, learning and memory and microRNA function has been awarded this prestigious honor. We extend our heartfelt Congratulations!

Royal Society of Canada Medals and Awards