Role of ShcA in regulating Breast tumor metabolism
Breast cancer, according to the Canadian Cancer Society, is one of the leading cause of death from cancer for Canadian women. Thus it is important to understand the underlying mechanisms to improve prevention and existing treatments of breast cancer for the well being of our future generations.
In the last decades, cancer research has increasingly emphasized on the importance of cellular bioenergetics in uncontrolled cell proliferation, irrespective of subtypes and drugs that target tumour metabolism and that are being explored as anti-cancer agents.
Our preliminary work reveals a novel connection between signaling and metabolism pathways highlighting the potential for convergence of these therapeutic strategies to treat poor outcome breast cancers.
The aim of my project is more precisely to define the pathways that fuel breast tumour growth and progression in order to rationally design combinatorial therapeutic strategies that increase sensitivity of breast cancers to drugs targeting signal transduction pathways and metabolism.
Overall my project brings health-related knowledge on poor outcome breast cancers and may have a profound impact in the future on cancer treatment options and outcomes.
Department of Biochemistry, McGill University
Postdoctoral fellow, Laboratory of Julie St-Pierre